Signal Transduction pathways that generate changes in gene expression constitute a powerful mechanism for regulating cellular processes. In the RNA Polymerase II family, we offer a powerful suite of monoclonal antibodies to polymerase and associated basal transcription machinery. The Protein Modification group brings together O-GlcNAc, ubiquitin, phosphotyrosine and PP2A antibodies for specific detection of these modifications that alter protein function. The Signal Transduction family is anchored by our exceptional cAMP/cGMP antibodies and is complemented by a new collection of Phospho-Specific antibodies. The Transcription Factor section includes developmentally active proteins such as Pax-6, Pax-2 and Krox-20.